— SAIGAO —

Product details

About The L-Arginine

I. Basic information

·Chemical name: L-arginine, the English name is “L-Arginine”, abbreviated as “Arg”, and its chemical system is named (2S)-2-amino-5-argininoic acid.

·Chemical formula: C₆H₁₄N₄O₂.

·Relative molecular mass: 174.20.

·CAS accession number: 74-79-3.

II. Structural features

·L – Arginine is a basic amino acid. Its molecular structure contains an amino group (-NH₂) and a carboxyl group (-COOH). The most notable feature is that it has a guanidine group (-NH-C) on its side chain. (=NH)-NH₂) structure. The guanidine group makes it highly alkaline under physiological pH conditions, and this special structure gives it unique chemical properties and diverse physiological functions, and can participate in a variety of important biochemical reactions.

III. Physical and chemical properties

·Appearance: white rhombus crystals or monoclinic flake crystals, odorless and bitter.

·Solubility: Easily soluble in water, slightly soluble in ethanol, almost insoluble in ether. Its good water solubility enables it to better participate in metabolism and other activities in various aqueous environments in organisms.

·Isoelectric point: about 10.76. At the isoelectric point, its net charge is zero and its solubility in the solution is relatively low. At this time, it is most likely to precipitate from the solution.

· Optical rotation: As an L-type amino acid, it has optical rotation and can rotate plane polarized light at a specific angle. This is also one of the important basis for identifying it from the D-type isomer.

IV. Source

·Natural sources: Widely found in various natural foods, such as meat, fish, poultry, dairy products and beans, etc. are good sources. It is a semi-essential amino acid for the human body. It is suitable for infants and young children and those who are in trauma, For people in special physiological states such as the recovery period from a disease, their own synthesis often cannot fully meet their needs and they need to supplement it from food.

·Industrial production sources: It can be produced through microbial fermentation, using specific microbial strains (such as certain genetically engineered bacteria), in a suitable fermentation medium (containing carbon sources, nitrogen sources, inorganic salts and other ingredients) and Under fermentation conditions (suitable temperature, pH, dissolved oxygen, etc.), L-arginine is synthesized through the metabolic pathway of microorganisms; in addition, chemical synthesis is also one of the ways to obtain it, but chemical synthesis usually requires complex chemical reaction steps. Fine separation and purification operations are also required, and problems such as separation of optical isomers must be solved to obtain high-purity L-arginine products that meet the requirements.

V. Physiological functions

·Participates in protein synthesis: It is an important component of protein structure, plays a key role in the construction of many biological macromolecules such as proteins, enzymes, and hormones, and is of great significance to maintaining normal physiological structure and functions of the human body.

· Nitric oxide synthesis: It is the precursor substance for the synthesis of nitric oxide (NO). Under the action of nitric oxide synthase (NOS) in the body, the guanidine nitrogen atom of L-arginine participates in the reaction to generate nitric oxide. Nitric oxide is an important signaling molecule that has many physiological effects such as relaxing blood vessels, regulating blood pressure, improving blood circulation, enhancing immune function, etc. For example, it can help maintain the normal tension and elasticity of blood vessels in the cardiovascular system.

·Regulate endocrine and metabolism: It plays a certain role in the regulation of hormone secretion, such as participating in the secretion regulation process of hormones such as insulin, and also plays an important role in the body’s urea cycle, helping to convert ammonia in the body into urea and excrete it from the body. Maintain the body’s nitrogen balance and ensure normal metabolism.

VI. Application areas

·Food industry: often used as nutritional fortifiers in some health foods, foods for special medical purposes, etc., to supplement necessary amino acids for the human body, especially for people who need to supplement arginine to meet special nutritional needs, such as fitness groups and the elderly. etc., helps to enhance physical fitness, improve immunity, etc.

·Pharmaceutical field: It is widely used and can be used to prepare a variety of amino acid infusions to supplement the body’s amino acid deficiency caused by disease, surgery, etc., and assist patients in recovery; in the treatment of certain cardiovascular diseases (such as hypertension, coronary heart disease, etc.) ), based on its ability to promote the production of nitric oxide and improve vascular function, it has certain medicinal development value; in addition, it is also involved in the treatment or auxiliary treatment of liver disease, male infertility and other diseases, such as helping Improve the detoxification function of the liver and improve sperm quality, etc.

· Cosmetic field: Added to some skin care products, it is often used because it promotes blood circulation, enhances skin cell metabolism, etc., helps improve the nutritional status of the skin, makes the skin healthier, and reduces the occurrence of wrinkles and other skin problems. Used in anti-aging and repair cosmetic products.

VII. Quality standards and testing

· Various countries and regions have formulated strict quality standards. For different uses (such as food grade, pharmaceutical grade, etc.), the purity of L-arginine, impurity content (including heavy metals, other amino acid impurities, etc.), optical rotation, Microbial limits and other indicators are clearly defined.

·Commonly used detection methods include high-performance liquid chromatography (HPLC), which accurately determines the content and purity of L-arginine in the sample by comparing its retention time, peak area and other parameters with standards; and automatic amino acid analyzers, It can analyze and detect multiple amino acids at the same time, conveniently and quickly determine the specific situation of L-arginine in the sample, and ensure that its quality meets the corresponding standard requirements.